Description

3-Fluoro-4-(Pyrrolidin-1-Ylmethyl)Phenylboronic Acid is a specialized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular architecture, featuring both a boronic acid group and a fluorinated pyrrolidine-substituted phenyl ring, makes it a valuable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides by enabling the introduction of the fluorinated pyrrolidine-phenyl moiety into lead structures.
• Material Science: Serves as a monomer or functionalization agent in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and bioconjugates due to the reactivity of the boronic acid group and the potential for target interaction from the fluorinated heterocycle.
• Catalyst Ligand Synthesis: Acts as a starting material for preparing sophisticated ligand systems used in asymmetric catalysis and transition metal complexes.

Basic Information

Item	Details
Product Name	3-Fluoro-4-(Pyrrolidin-1-Ylmethyl)Phenylboronic Acid
CAS No.	1333394-28-7
Molecular Formula	C₁₁H₁₅BFNO₂
Molecular Weight	223.05 g/mol
Synonyms	3-Fluoro-4-(pyrrolidin-1-ylmethyl)benzeneboronic acid; (3-Fluoro-4-((pyrrolidin-1-yl)methyl)phenyl)boronic acid; 4-(Pyrrolidin-1-ylmethyl)-3-fluorophenylboronic acid; B-[3-Fluoro-4-(1-pyrrolidinylmethyl)phenyl]boronic acid; 1333394-28-7; 3-Fluoro-4-(pyrrolidin-1-ylmethyl)phenylboronic acid pinacol ester (common precursor); 3-Fluoro-4-(N-pyrrolidinylmethyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-(Pyrrolidin-1-Ylmethyl)Phenylboronic Acid is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.