Description

3-Fluoro-4-(Morpholinomethyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining the versatile Suzuki-Miyaura cross-coupling capability of the boronic acid group with the morpholine moiety, which is a privileged structure in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly for creating complex biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds between aryl and heteroaryl groups.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific fluorinated and morpholine-containing scaffolds.
• Material Science: Employed in the synthesis of advanced organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals, where precise molecular architecture is required.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of chemical probes to study biological systems.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening (HTS) in early-stage drug discovery programs.

Basic Information

Product Name	3-Fluoro-4-(Morpholinomethyl)Phenylboronic Acid
CAS No.	1333388-00-3
Molecular Formula	C11H15BFNO3
Molecular Weight	239.05 g/mol
Synonyms	(3-Fluoro-4-(morpholinomethyl)phenyl)boronic acid; 4-(Morpholinomethyl)-3-fluorobenzeneboronic acid; 3-Fluoro-4-morpholin-4-ylmethylbenzeneboronic acid; B-[3-Fluoro-4-(morpholinomethyl)phenyl]boronic acid; 3-Fluoro-4-(4-morpholinylmethyl)benzeneboronic Acid; 1333388-00-3; 3-Fluoro-4-morpholinomethylphenylboronic Acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Morpholinomethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.