Description

(5-Fluoro-2-((4-Methylpiperazin-1-Yl)Methyl)Phenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic acid functional group integrated with a piperazine moiety. This compound is critical for facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for targeted cancer therapies and neurological disorders.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl halides and boronic acids, essential for creating complex molecular architectures in medicinal chemistry.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new synthetic pathways and creating libraries of compounds for biological screening.
• Ligand Synthesis: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Potential use in developing antibody-drug conjugates (ADCs) and other bioconjugate platforms due to the reactivity of the boronic acid group.

Basic Information

Product Name	(5-Fluoro-2-((4-Methylpiperazin-1-Yl)Methyl)Phenyl)Boronic Acid
CAS No.	1333387-98-6
Molecular Formula	C12H18BFN2O2
Molecular Weight	252.10 g/mol
Synonyms	[5-Fluoro-2-[(4-methyl-1-piperazinyl)methyl]phenyl]boronic acid; (5-Fluoro-2-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid; 2-[(4-Methylpiperazin-1-yl)methyl]-5-fluorophenylboronic acid; Boronic acid, B-[5-fluoro-2-[(4-methyl-1-piperazinyl)methyl]phenyl]-; 5-Fluoro-2-((4-methylpiperazin-1-yl)methyl)benzeneboronic acid; 1333387-98-6; CAS 1333387-98-6
EINECS	Contact for details

Quality Control

Our (5-Fluoro-2-((4-Methylpiperazin-1-Yl)Methyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.