Description

Carbamic Acid, n-[(1S)-1-[[[(1S)-1-(Hydroxymethyl)-2-(2-Oxo-3-Pyrrolidinyl)Ethyl]Amino]Carbonyl]-3-Methylbutyl]-, Phenylmethyl Ester is a high-purity, chiral carbamate derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block or intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the synthesis of complex, stereospecific drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of proprietary drug candidates, particularly protease inhibitors or other enzyme-targeted therapies.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics due to its structural similarity to amino acid derivatives and the presence of a pyrrolidinone moiety.
• API Development: Serves as a critical precursor in the research and process development of new chemical entities (NCEs) requiring high stereochemical purity.
• Bioconjugation Chemistry: The reactive carbamate and ester functional groups make it suitable for creating targeted drug conjugates or prodrugs.
• Chemical Biology Probes: Employed in the synthesis of specialized molecular probes for studying enzyme function and biological pathways.
• Process Chemistry Optimization: Used by process chemists to develop scalable and efficient synthetic routes for complex molecules.

Basic Information

Item	Detail
Product Name	Carbamic Acid, n-[(1S)-1-[[[(1S)-1-(Hydroxymethyl)-2-(2-Oxo-3-Pyrrolidinyl)Ethyl]Amino]Carbonyl]-3-Methylbutyl]-, Phenylmethyl Ester
CAS No.	1333231-43-8
Molecular Formula	C21H31N3O5
Molecular Weight	405.49 g/mol
Synonyms	(S)-Benzyl (1-(((S)-1-(hydroxymethyl)-2-(2-oxopyrrolidin-3-yl)ethyl)carbamoyl)-3-methylbutyl)carbamate; (3S)-3-[[(2S)-2-[[(2S)-2-(Benzyloxycarbonylamino)-4-methylpentanoyl]amino]-3-hydroxypropyl]carbamoyl]pyrrolidin-2-one; Chiral Carbamate Pyrrolidinone Derivative; N-Cbz-Protected Dipeptide Mimetic Intermediate; Z-L-Leu-L-Homoser-Pyrrolidinone Intermediate
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols suitable for pharmaceutical R&D applications. Every batch is characterized to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are provided, detailing key parameters such as assay (HPLC), chiral purity, and impurity profiles. Our quality system is designed to support cGMP compliance for investigational materials, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.