Description

Upacicalcet is a high-purity pharmaceutical intermediate and active ingredient used in the development of novel therapeutic agents. This compound is critical for research and manufacturing processes requiring precise chemical control and reliable supply chains. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers targeting the development of calcimimetic agents and related treatments for mineral metabolism disorders.

Application

• Pharmaceutical Active Ingredient (API): Serves as a key intermediate or active component in the synthesis of calcimimetic drugs.
• Research & Development: Used in preclinical and clinical research for studying calcium-sensing receptor (CaSR) modulation and related metabolic pathways.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Integral to scale-up and optimization of synthetic routes for related therapeutic compounds in pilot and commercial production.
• Biochemical Research: Utilized in studies investigating disorders of mineral and bone metabolism, such as secondary hyperparathyroidism.

Basic Information

Product Name	Upacicalcet
CAS No.	1333218-50-0
Molecular Formula	C22H25F2N3O5S
Molecular Weight	481.51 g/mol
Synonyms	Upacicalcet; (R)-N-((1H-Pyrazol-1-yl)methyl)-1-(naphthalen-1-yl)ethan-1-amine; UNII-0J8P3J2V3B; 1333218-50-0; (R)-N-((1H-Pyrazol-1-yl)methyl)-1-(naphthalen-1-yl)ethanamine; Calcimimetic agent Upacicalcet; Upacicalcet (USAN)
EINECS	Contact for details

Quality Control

Our Upacicalcet is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR, MS), and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with cGMP guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay (HPLC)	97.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.