Description

4-((Diethylamino)Methyl)-3-Fluorophenylboronic Acid is a specialized organoboron compound featuring a diethylaminomethyl substituent and a fluorine atom on the phenyl ring, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its dual functionality, where the boronic acid group enables key cross-coupling reactions, and the tertiary amine moiety can serve as a directing group or a handle for further modification. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex molecular architectures via Suzuki-Miyaura coupling.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura coupling.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require fluorinated and amine-functionalized aromatic structures.
• Material Science: Serves as a monomer or functionalizing agent in the creation of advanced polymers, liquid crystals, or organic electronic materials.
• Chemical Biology & Probe Development: Utilized for synthesizing fluorescent probes, enzyme inhibitors, or other bioactive molecules where the fluorine and amine groups are critical for target interaction.
• Catalyst Ligand Synthesis: The boronic acid and amine functionalities can be used to construct novel bidentate or tridentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis houses serving the life sciences sector with tailored, complex boronic acid derivatives.

Basic Information

Product Name	4-((Diethylamino)Methyl)-3-Fluorophenylboronic Acid
CAS No.	1333121-78-0
Molecular Formula	C11H17BFNO2
Molecular Weight	225.07 g/mol
Synonyms	[4-(Diethylaminomethyl)-3-fluorophenyl]boronic acid; 3-Fluoro-4-[(diethylamino)methyl]benzeneboronic acid; 4-(Diethylaminomethyl)-3-fluorobenzeneboronic acid; B-[4-[(Diethylamino)methyl]-3-fluorophenyl]boronic acid; 4-(Diethylaminomethyl)-3-fluorophenylboronic acid pinacol ester (common protected form); 3-Fluoro-4-(N,N-diethylaminomethyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our production of 4-((Diethylamino)Methyl)-3-Fluorophenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP compliance for pharmaceutical development and is adaptable to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.