Description

2-(tert-Butoxymethyl)-5-Fluorophenylboronic Acid is a specialized organoboron compound that serves as a crucial building block in modern synthetic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic frameworks.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is critical.
• Suzuki-Miyaura Cross-Coupling: A fundamental reagent for forming carbon-carbon bonds between aromatic rings in medicinal chemistry and complex molecule synthesis.
• Ligand and Catalyst Development: Serves as a starting material for creating novel boron-containing ligands used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and target engagement.

Basic Information

Product Name	2-(tert-Butoxymethyl)-5-Fluorophenylboronic Acid
CAS No.	1332650-85-7
Molecular Formula	C11H16BFO3
Molecular Weight	226.06 g/mol
Synonyms	[2-[(1,1-Dimethylethoxy)methyl]-5-fluorophenyl]boronic Acid; 5-Fluoro-2-[(2-methyl-2-propanyloxy)methyl]benzeneboronic Acid; 2-(tert-Butoxymethyl)-5-fluorobenzeneboronic Acid; 2-(tert-ButoxyMethyl)-5-FluoroPhenylBoronic Acid; 2-(tert-Butoxymethyl)-5-fluorophenylboronic acid pinacol ester (common precursor); 2-(tert-Butyloxymethyl)-5-fluorophenylboronic acid; B-[2-[(1,1-Dimethylethoxy)methyl]-5-fluorophenyl]boronic Acid
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxymethyl)-5-Fluorophenylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.