Description

[2-Fluoro-4-(Hydroxymethyl)Phenyl]Boronic Acid is a versatile and high-value boronic acid derivative, a key building block in modern synthetic chemistry. Its bifunctional structure, featuring both a boronic acid group and a hydroxymethyl substituent on a fluorinated aromatic ring, makes it a critical intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for Suzuki-Miyaura cross-coupling reactions to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a key coupling partner with aryl/vinyl halides to form biaryl and other C-C bonds under mild conditions.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes, sensors, and inhibitors that leverage boronic acid-diol interactions for studying biological processes.
• Ligand for Catalysis: The structure can be modified to create novel ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	[2-Fluoro-4-(Hydroxymethyl)Phenyl]Boronic Acid
CAS No.	1331945-14-2
Molecular Formula	C7H8BFO3
Molecular Weight	169.95 g/mol
Synonyms	(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid; 2-Fluoro-4-(hydroxymethyl)benzeneboronic acid; 4-Borono-3-fluorobenzyl alcohol; (4-(Hydroxymethyl)-2-fluorophenyl)boronic acid; B-(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid; 2-Fluoro-4-(hydroxymethyl)phenylboronic acid; 2-Fluoro-4-hydroxymethylphenylboronic Acid
EINECS	Contact for details

Quality Control

Our [2-Fluoro-4-(Hydroxymethyl)Phenyl]Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.