Description

Valsartan-D3 CAS NO 1331908-02-1 is a stable isotope-labeled analog of the widely prescribed antihypertensive drug, Valsartan, where three hydrogen atoms are replaced by deuterium. This compound is an essential internal standard for the accurate quantification of Valsartan in biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology, ensuring precise and reliable pharmacokinetic and bioequivalence studies.

Application

• LC-MS/MS Internal Standard: Primary use as a deuterated internal standard for the precise quantification of Valsartan in plasma, serum, and urine during bioanalytical method development and validation.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioequivalence Testing: Critical for comparing the bioavailability of generic Valsartan formulations to the branded reference product in regulatory submissions.
• Forensic & Clinical Toxicology: Used in assays to confirm Valsartan presence and concentration in cases of overdose monitoring or compliance testing.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating assay methods for Valsartan drug substance and product manufacturing.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the spike material in this gold-standard technique for achieving the highest analytical accuracy.

Basic Information

Product Name	Valsartan-D3
CAS No.	1331908-02-1
Molecular Formula	C24H26D3N5O3
Molecular Weight	438.53 g/mol
Synonyms	L-Valine, N-(1-oxopentyl)-N-[[2'-(2H3)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-; (2S)-3-Methyl-2-[pentanoyl-[[4-[2-(2H3-1H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid; Valsartan-d3; Deuterated Valsartan; Valsartan (phenyl-d3); N-Valeryl-N-[[2'-(2H3)-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-L-valine
EINECS	Contact for details

Quality Control

Our Valsartan-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We support research and regulatory compliance needs with materials traceable to high-purity reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.