Description

o-Desmethyl Mycophenolic Acid Methyl Ester-D3 is a deuterium-labeled internal standard critical for accurate quantitative analysis in bioanalytical studies. This high-purity compound is essential for ensuring precision and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolic research. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers working with mycophenolic acid and its derivatives.

Application

• Primary use as a deuterated internal standard for the quantification of mycophenolic acid and its metabolites in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for immunosuppressant drugs.
• Enables precise therapeutic drug monitoring (TDM) in clinical research settings.
• Supports drug metabolism and disposition (DMPK) investigations during pharmaceutical development.
• Used in the development and validation of regulatory-compliant bioanalytical methods (e.g., following FDA/EMA guidelines).
• Facilitates research into the mechanisms of action and metabolic pathways of immunosuppressive agents.

Basic Information

Item	Detail
Product Name	o-Desmethyl Mycophenolic Acid Methyl Ester-D3
CAS No.	1331670-20-2
Molecular Formula	C18H17D3O5
Molecular Weight	319.36 g/mol (approx.)
Synonyms	6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid Methyl Ester-d3; (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic Acid Methyl Ester-d3; MPA Metabolite-d3; Mycophenolic Acid Metabolite-d3; o-Desmethyl MPA Methyl Ester-D3; Deuterated Mycophenolic Acid Derivative; Internal Standard for MPA
EINECS	Contact for details

Quality Control

Every batch of o-Desmethyl Mycophenolic Acid Methyl Ester-D3 is manufactured and tested to meet the stringent requirements for analytical reference standards. Our quality assurance includes rigorous identity confirmation, purity assessment by HPLC, and verification of isotopic enrichment. Certificates of Analysis (COA) detailing batch-specific results are provided, ensuring traceability and compliance with relevant pharmacopeial and ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.