Description

Benfotiamine-D5 is a deuterated analog of the synthetic, fat-soluble S-acyl derivative of thiamine (Vitamin B1). This stable isotope-labeled compound is essential for advanced analytical research and development, providing a critical internal standard for precise quantification. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolic studies, pharmacokinetic research, and the development of novel thiamine-based therapeutics.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical reference compound for the accurate quantification of benfotiamine and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolic Pathway Investigation: Used as a tracer to elucidate the metabolic fate and conversion pathways of benfotiamine in vivo.
• Drug Development and Formulation: Supports the development and validation of robust analytical methods for new pharmaceutical formulations containing benfotiamine.
• Quality Control in Manufacturing: Can be employed in high-purity analytical labs for method development and quality assurance of benfotiamine active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Benfotiamine-D5
CAS No.	1331669-97-6
Molecular Formula	C19H18D5N4O3PS
Molecular Weight	425.49 g/mol
Synonyms	S-Benzoylthiamine O-monophosphate-d5; Benfotiamine-d5; [D5]-Benfotiamine; O-Monophosphoric acid ester of S-benzoylthiamine-d5; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-{[d5-phenyl]carbonyloxy}ethyl)-4-methylthiazolium-d5 inner salt monophosphate; BFT-d5; Vitamin B1 derivative-d5
EINECS	Contact for details

Quality Control

Our Benfotiamine-D5 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by comprehensive analytical documentation, including detailed Certificates of Analysis (COA) that report isotopic enrichment (D-content), chemical purity by HPLC, and confirmation of structure by NMR and MS. We adhere to cGMP principles for the production of reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.