Description

Caffeic Acid Benzyl Ester-D5 is a deuterated derivative of caffeic acid phenethyl ester (CAPE), a bioactive compound of significant research interest. This isotopically labeled analog is specifically designed for use as an internal standard in quantitative analytical methods, ensuring high accuracy and reliability in measurement. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and life science sectors who require precise quantification of caffeic acid derivatives in complex matrices.

Application

• Internal Standard for LC-MS/MS and GC-MS: Primary application for the accurate quantification of caffeic acid phenethyl ester (CAPE) and related phenolic compounds in biological samples, plant extracts, and finished products.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for CAPE and its analogs in preclinical and clinical research.
• Bioavailability and Formulation Analysis: Used to measure the concentration and stability of active ingredients in pharmaceutical and nutraceutical formulations.
• Food and Natural Product Analysis: Facilitates the quantification of caffeic acid esters in propolis, honey, and other natural products for quality control and authenticity verification.
• Reference Material for Method Development: Serves as a critical calibrant for developing and validating robust analytical methods in compliance with GLP and GMP guidelines.

Basic Information

Product Name	Caffeic Acid Benzyl Ester-D5
CAS No.	1331655-92-5
Molecular Formula	C16H8D5O4
Molecular Weight	~273.31 g/mol
Synonyms	CAPE-Benzyl Ester-d5; 3,4-Dihydroxycinnamic Acid Benzyl Ester-d5; Benzyl (E)-3-(3,4-dihydroxyphenyl)acrylate-d5; Caffeic Acid Benzyl-d5 Ester; Deuterated Caffeic Acid Benzyl Ester; (2E)-3-(3,4-Dihydroxyphenyl)acrylic Acid Benzyl-d5 Ester; Benzyl 3-(3,4-Dihydroxyphenyl)acrylate-d5
EINECS	Contact for details

Quality Control

Our Caffeic Acid Benzyl Ester-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm isotopic purity, chemical purity, and structural identity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on assay, isotopic enrichment, and impurity profiles, supporting traceability and compliance with research and quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.