Description

Z-Ser(Trt)-OH is a protected serine derivative, specifically the N-benzyloxycarbonyl (Z) and O-trityl (Trt) protected form of L-serine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it provides orthogonal protection for the serine side chain, preventing unwanted side reactions during peptide chain assembly. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the controlled incorporation of serine into peptide sequences.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Serves as a precursor for introducing functional handles or labels onto peptides via its selectively deprotectable side chain.
• Combinatorial Chemistry: A valuable reagent in libraries for drug discovery and high-throughput screening of bioactive peptides.
• Academic and Industrial R&D: Fundamental for studying peptide structure, function, and developing novel peptide therapeutics.

Basic Information

Product Name	Z-Ser(Trt)-OH
CAS No.	1330286-53-7
Molecular Formula	C30H27NO5
Molecular Weight	481.54 g/mol
Synonyms	N-Carbobenzoxy-O-trityl-L-serine; Z-O-Trityl-L-serine; Nα-(Benzyloxycarbonyl)-O-trityl-L-serine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-oxo-3-(trityloxy)propanoic acid; Fmoc-Ser(Trt)-OH (Note: This is the Fmoc-protected variant); Z-Ser(Trt); CBZ-Ser(Trt)-OH; L-Serine, N-[(phenylmethoxy)carbonyl]-, 1-(triphenylmethyl) ester
EINECS	Contact for details

Quality Control

Our Z-Ser(Trt)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with the rigorous standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.