Description

2-Amino-6-Mercaptopurine-13C2,15N is a stable isotope-labeled analog of the purine antimetabolite 6-mercaptopurine, specifically enriched with carbon-13 and nitrogen-15. This compound is essential for advanced analytical research, providing an internal standard for precise quantification and metabolic pathway tracing in complex biological matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Critical for accurate quantification of 6-mercaptopurine and its metabolites in bioanalytical assays, ensuring method validity and regulatory compliance.
• Drug Metabolism Studies (DMPK): Used as a tracer to elucidate metabolic pathways, identify metabolites, and study the pharmacokinetic profile of 6-mercaptopurine in preclinical and clinical research.
• Stable Isotope Dilution Assays: Enables highly precise and sensitive measurement of 6-mercaptopurine levels in patient plasma, serum, or other biological fluids for therapeutic drug monitoring (TDM).
• Biomedical Research: Facilitates research into the mechanisms of action, resistance, and toxicity of thiopurine drugs in oncology and immunology.
• Method Development & Validation: Serves as a key component in developing and validating robust analytical methods according to FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and ensuring the quality and consistency of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Amino-6-Mercaptopurine-13C2,15N
CAS No.	1330266-29-9
Molecular Formula	C313C2H515N4S
Molecular Weight	~169.13 g/mol (exact mass varies with isotopic enrichment)
Synonyms	6-Mercaptopurine-13C2,15N (2-amino-); 6-Thiohypoxanthine-13C2,15N; 6-MP-13C2,15N; 2-Amino-6-purinethiol-13C2,15N; 1,7-Dihydro-6H-purine-6-thione-2-amino-13C2,15N; Leukerin-13C2,15N (labeled analog); Purinethol-13C2,15N (labeled analog); Isotopically Labeled 6-Mercaptopurine
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-6-Mercaptopurine-13C2,15N is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (by MS), and identification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment aligns with the standards expected for research-grade chemicals in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % 13C; ≥ 98 atom % 15N
Chemical Purity (Assay)	≥ 90% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.