Description

Adapalene-D6 Methyl Ester is a deuterated isotopologue of the methyl ester derivative of adapalene, a synthetic retinoid. This stable-labeled compound is of critical importance as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based analyses. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development, pharmacokinetic study, and quality control of retinoid-based dermatological products.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of adapalene and its metabolites in biological matrices (e.g., plasma, skin tissue).
• Pharmaceutical Research & Development: Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) studies during the drug development process for acne treatments.
• Bioanalytical Method Validation: Essential for developing and validating robust, GLP-compliant analytical methods in regulatory submissions.
• Metabolite Identification and Profiling: Aids in the identification and quantification of drug metabolites in stability and metabolism studies.
• Quality Control in API Manufacturing: Used in advanced QC laboratories to monitor and ensure the purity and consistency of active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Adapalene-D6 Methyl Ester
CAS No.	1330264-23-7
Molecular Formula	C29H30D6O3
Molecular Weight	438.62 g/mol
Synonyms	6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid Methyl Ester-d6; Methyl 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoate-d6; Adapalene Methyl Ester-d6; CD 271 Methyl Ester-d6; Differin Methyl Ester-d6; (6-{3-[Tricyclo[3.3.1.13,7]dec-1-yl]-4-methoxyphenyl}-2-naphthyl)methyl-d6 Carboxylate
EINECS	Contact for details

Quality Control

Our Adapalene-D6 Methyl Ester is manufactured under strict quality systems to ensure it meets the exacting requirements for use as an internal standard. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C) for structural confirmation and deuterium incorporation, and HPLC and LC-MS for purity and isotopic enrichment assessment. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, chemical purity, isotopic purity, and suitability for its intended analytical use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.