Description

Xipamide-D6 is a deuterium-labeled analog of the diuretic pharmaceutical compound Xipamide, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative analysis of Xipamide in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used to track and quantify the parent drug and its metabolites, enabling precise pharmacokinetic profiling.
• Bioanalytical Method Development and Validation: Essential for creating robust, accurate, and reproducible analytical methods compliant with FDA and EMA guidelines.
• Clinical and Pre-clinical Research: Supports bioavailability, bioequivalence, and toxicokinetic studies requiring high-sensitivity detection.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability-indicating assay methods for drug substance and product analysis.

Basic Information

Product Name	Xipamide-D6
CAS No.	1330262-09-3
Molecular Formula	C15H7D6ClN2O4S
Molecular Weight	357.83 g/mol (for D6 labeled form)
Synonyms	4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide-D6; 4-Chloro-5-sulfamoylsalicyl-o-xylidide-D6; Aquaphor-D6; Aquex-D6; Diurexan-D6; Zipamide-D6; Xipamid-D6; [2H6]-Xipamide
EINECS	Contact for details

Quality Control

Every batch of Xipamide-D6 is manufactured and tested under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic analyses, to ensure compliance with industry standards for stable isotope-labeled compounds. Certificates of Analysis (COA) detailing isotopic enrichment (e.g., D6, ≥98%), chemical purity (by HPLC), and specific analytical data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	D6, ≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.