Description

Dapsone Hydroxylamine-D4 is a deuterated analog of a key intermediate used in the synthesis and analytical profiling of dapsone and related sulfone compounds. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry, serving as an internal standard to correct for variations in sample preparation and instrument response. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, bioanalytical method development, and drug metabolism research.

Application

• Internal standard for the LC-MS/MS quantification of Dapsone and its metabolites in biological matrices (plasma, serum, urine).
• Critical reagent in pharmacokinetic (PK) and bioequivalence studies for sulfone-class pharmaceuticals.
• Use in deuterium-labeled tracer studies to investigate metabolic pathways and drug-drug interactions.
• Reference material for the validation of analytical methods in compliance with GLP and ICH guidelines.
• Chemical intermediate in the synthesis of isotopically labeled drug substances for advanced research.
• Component in high-purity certified reference materials (CRMs) for quality control laboratories.

Basic Information

Product Name	Dapsone Hydroxylamine-D4
CAS No.	1330185-26-6
Molecular Formula	C12H8D4N2O2S
Molecular Weight	252.33 g/mol
Synonyms	4,4'-Sulfonylbis[2,3,5,6-tetradeuterioaniline] N-Oxide; 4-Amino-4'-aminodiphenyl sulfone hydroxylamine-d4; Dapsone-d4 hydroxylamine; DDS hydroxylamine-d4; [2H4]-Dapsone hydroxylamine; 4,4'-Diaminodiphenyl sulfone hydroxylamine-d4; Deuterated Dapsone Hydroxylamine
EINECS	Contact for details

Quality Control

Every batch of Dapsone Hydroxylamine-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments, including detailed reporting on chemical purity, isotopic enrichment, and impurity profiles. Certificates of Analysis (COA) are available upon request, detailing results from NMR, HPLC, and MS analyses to confirm identity, purity, and deuterium incorporation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.