Description

(1S,4R)-4-(3,4-Dichlorophenyl)-n-(Trideuteriomethyl)-1,2,3,4-Tetrahydronaphthalen-1-Amine:Hydrochloride is a high-purity, deuterated pharmaceutical intermediate and reference standard. This compound is critical for advanced research and development in medicinal chemistry, particularly for metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutic agents.

Application

• Deuterated Pharmaceutical Intermediate: Used in the synthesis of deuterated drug candidates to enhance metabolic stability and alter pharmacokinetic profiles.
• Metabolic Study Standard: Serves as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for accurate quantification in biological matrices.
• Pharmacokinetics (PK) and Absorption, Distribution, Metabolism, and Excretion (ADME) Research: Essential for tracing and understanding the fate of drug molecules in vivo.
• Neurological Research: Potential tool for investigating pathways related to its structural analogs in central nervous system (CNS) disorders.
• Process Chemistry & Scale-up: Supports the development and optimization of synthetic routes for complex, isotopically labeled molecules.
• Quality Control & Method Development: Acts as a certified reference material (CRM) for validating analytical methods in quality assurance laboratories.

Basic Information

Product Name	(1S,4R)-4-(3,4-Dichlorophenyl)-n-(Trideuteriomethyl)-1,2,3,4-Tetrahydronaphthalen-1-Amine:Hydrochloride
CAS No.	1330180-66-9
Molecular Formula	C18H17D3Cl2N•HCl
Molecular Weight	Contact for details
Synonyms	(1S,4R)-4-(3,4-Dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride; (1S,4R)-4-(3,4-Dichlorophenyl)-N-(trideuteromethyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride; Deuterated Sertraline Impurity; Sertraline-d3 Hydrochloride; (1S,4R)-N-Methyl-d3-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine hydrochloride; Zoloft-d3 Hydrochloride; Lustral-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data, including HPLC purity, isotopic enrichment (D-content), and identification by NMR and MS. Certificates of Analysis (COA) are available upon request, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.