Description

(4R,5R)-5-(2,4-Difluorophenyl)-4-Methyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-2-Oxazolidinone-D3 is a deuterated isotopologue of a key oxazolidinone derivative, offering enhanced metabolic stability for advanced research and development. This high-purity compound is critical for pharmaceutical applications, particularly in the development of novel antifungal agents and as a stable isotope-labeled internal standard for precise analytical quantification. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in drug discovery, metabolism studies, and high-accuracy mass spectrometry.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and method validation in antifungal drug analysis.
• Metabolic Stability Studies: Used as a deuterium-labeled tracer in ADME (Absorption, Distribution, Metabolism, Excretion) studies to investigate drug metabolism pathways.
• Mass Spectrometry Internal Standard: Essential for quantitative LC-MS/MS analysis, improving accuracy and precision by correcting for matrix effects and instrument variability.
• Drug Discovery & Development: A key intermediate or building block in the synthesis and optimization of new triazole-containing antifungal candidates.
• Mechanism of Action Research: Employed in biochemical assays to study the interaction and inhibition of fungal lanosterol 14α-demethylase.
• Regulatory Submissions: Supports the development of regulatory dossiers by providing definitive characterization data for new drug applications.

Basic Information

Product Name	(4R,5R)-5-(2,4-Difluorophenyl)-4-Methyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-2-Oxazolidinone-D3
CAS No.	1330176-89-0
Molecular Formula	C14H12D3F2N3O2
Molecular Weight	292.30 g/mol
Synonyms	Deuterated Fluconazole Impurity; (4R,5R)-5-(2,4-Difluorophenyl)-4-Methyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-2-Oxazolidinone-d3; 2-Oxazolidinone, 5-(2,4-difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, (4R,5R)-, D3-labeled; Fluconazole Related Compound D3; Fluconazole-d3 Derivative; Triazole Antifungal Deuterated Standard
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing comprehensive analytical results from techniques including HPLC, NMR, and MS to confirm identity, chemical purity, isotopic enrichment, and impurity profile. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.