Description

Rac n-Demethyl Promethazine CAS NO 1330173-19-7 is a key pharmaceutical intermediate and reference standard used in the development and quality control of active pharmaceutical ingredients (APIs). This compound is of significant importance for research and manufacturing processes that require high-purity chemical building blocks. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of antihistamine and phenothiazine-derived therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthetic pathway for novel phenothiazine-based drug candidates.
• Analytical Reference Standard: Used for method development, validation, and quantification in HPLC, LC-MS, and GC-MS analyses within quality control laboratories.
• Metabolite Studies: Serves as a reference compound in pharmacokinetic and drug metabolism research to understand biotransformation pathways.
• Process Chemistry Research: Employed in route scouting and optimization for the scalable synthesis of related pharmaceutical actives.
• Impurity Profiling: Essential for identifying and characterizing potential genotoxic impurities or degradation products in promethazine and related API batches.

Basic Information

Product Name	Rac n-Demethyl Promethazine
CAS No.	1330173-19-7
Molecular Formula	C16H18N2S
Molecular Weight	270.40 g/mol
Synonyms	N-Desmethyl Promethazine; Promethazine N-Oxide Impurity; (±)-N-Desmethylpromethazine; 10H-Phenothiazine-10-ethanamine, N,α-dimethyl-, N-oxide; Racemic Desmethyl Promethazine; Promethazine Metabolite; Phenothiazine Derivative Intermediate
EINECS	Contact for details

Quality Control

Our Rac n-Demethyl Promethazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.