Description

Acetyl Isoniazid-D4 is a deuterated analog of the anti-tuberculosis drug isoniazid, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reliability in analytical results. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS analysis of Isoniazid and its metabolites.
• Quantitative bioanalysis in preclinical and clinical pharmacokinetic studies.
• Drug metabolism and disposition (DMPK) research to track drug pathways.
• Development and validation of GLP/GCP-compliant analytical methods.
• Quality control and impurity profiling in pharmaceutical manufacturing.
• Stable isotope dilution assays for enhanced analytical precision.
• Reference material for forensic and anti-doping testing protocols.

Basic Information

Product Name	Acetyl Isoniazid-D4
CAS No.	1330169-81-7
Molecular Formula	C8H5D4N3O
Molecular Weight	163.19 g/mol
Synonyms	N-Acetylisoniazid-d4; 4-Pyridinecarboxylic acid, hydrazide-d4, N-acetyl-; Isonicotinic acid hydrazide-d4, N-acetyl-; Acetylhydrazine-d4, isonicotinoyl-; Isoxyl-d4 (metabolite); Isoniazid Acetyl-d4; INH Acetyl-d4; Deuterated Acetyl Isoniazid
EINECS	Contact for details

Quality Control

Our Acetyl Isoniazid-D4 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for critical analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and confirmation of structure. We adhere to relevant standards for high-purity reference materials to support GLP and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.