Description

3’-Mercaptoacetaminophen-D6 Disulfide is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is specifically designed for use in quantitative mass spectrometry, providing unmatched accuracy and reliability in trace-level analysis. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and environmental monitoring sectors who require precise measurement of acetaminophen and its metabolites.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of acetaminophen (paracetamol) and its metabolites in complex biological matrices.
• Pharmaceutical R&D and Bioanalysis: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies, drug metabolism and disposition (DMPK) research, and bioequivalence testing to ensure data integrity.
• Clinical and Forensic Toxicology: Enables precise measurement of acetaminophen levels in plasma, serum, or urine for therapeutic drug monitoring (TDM) and overdose cases.
• Environmental and Food Safety Testing: Facilitates the detection and quantification of pharmaceutical residues in environmental water samples and food products.
• Method Development and Validation: A key component in developing and validating robust, regulatory-compliant analytical methods (following FDA, EMA, ICH guidelines).
• Metabolite Profiling and Identification: Aids in the structural elucidation and tracking of sulfur-containing metabolite pathways of acetaminophen.

Basic Information

Product Name	3’-Mercaptoacetaminophen-D6 Disulfide
CAS No.	1330165-42-8
Molecular Formula	C16H10D6N2O4S2
Molecular Weight	Contact for details
Synonyms	N-(4-Hydroxyphenyl)-3,3'-dithiobis[acetamide]-D6; Acetaminophen D6 Disulfide Metabolite; Paracetamol D6 Disulfide Derivative; 3,3'-Dithiobis[N-(4-hydroxyphenyl)acetamide]-D6; APAP-D6 Disulfide; Deuterated Acetaminophen Disulfide; N-Acetyl-p-benzoquinone imine (NAPQI) Trapping Agent-D6; Deuterium Labeled Internal Standard for Acetaminophen
EINECS	Contact for details

Quality Control

Every batch of 3’-Mercaptoacetaminophen-D6 Disulfide is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of quantitative analysis. Comprehensive testing includes identity confirmation, assay, and determination of isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your method validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, store at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.