Description

Ethacrynic Acid-D5 is a deuterated analog of the loop diuretic ethacrynic acid, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research and development, clinical laboratories, and forensic toxicology studies requiring precise quantification of ethacrynic acid.

Application

• Internal Standard for LC-MS/MS: Primary application in quantitative bioanalysis for pharmacokinetic and metabolomic studies.
• Pharmaceutical R&D: Used in drug metabolism and disposition (DMPK) studies to track the parent drug and metabolites.
• Clinical Research: Enables accurate measurement of ethacrynic acid levels in patient plasma or serum for therapeutic drug monitoring.
• Forensic and Anti-Doping Analysis: Provides definitive quantification in complex biological matrices for regulatory and compliance testing.
• Method Development and Validation: Serves as a critical component in developing robust, GLP-compliant analytical methods.
• Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry.

Basic Information

Product Name	Ethacrynic Acid-D5
CAS No.	1330052-59-9
Molecular Formula	C13H7D5Cl2O4
Molecular Weight	306.16 g/mol (for monoisotopic)
Synonyms	[2,3-Dichloro-4-(2-ethylidenebutanoyl)phenoxy]acetic-2,2,3,4,4-d5 Acid; Ethacrynic Acid (phenyl-d5); Ethacrynic Acid-d5; Etacrynic Acid-d5; MK-595-d5; Edecrin-d5; (2,3-Dichloro-4-(2-methylenebutyryl)phenoxy)acetic-d5 Acid; Deuterated Ethacrynic Acid
EINECS	Contact for details

Quality Control

Every batch of Ethacrynic Acid-D5 is manufactured and tested under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% chemical purity, ≥99% isotopic enrichment), and suitability for use as an internal standard. Our quality commitment ensures compliance with the rigorous standards required for pharmaceutical and clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.