Description

(R)-(+)-Celiprolol-D9 Hydrochloride CAS NO 1330045-90-3 is a high-purity, deuterated isotopologue of the β-adrenergic blocker celiprolol, specifically labeled with nine deuterium atoms. This compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolism studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Enabling precise quantification of celiprolol and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Supporting pharmacokinetic (PK) and pharmacodynamic (PD) studies during clinical trials and preclinical development.
• Facilitating drug metabolism and disposition (DMPK) research to understand absorption, distribution, metabolism, and excretion (ADME) profiles.
• Ensuring data integrity and meeting stringent regulatory requirements for submissions to agencies like the FDA and EMA.
• Application in forensic and clinical toxicology for the accurate detection and measurement of celiprolol.

Basic Information

Product Name	(R)-(+)-Celiprolol-D9 Hydrochloride
CAS No.	1330045-90-3
Molecular Formula	C20H24D9N3O4•HCl
Molecular Weight	Approx. 432.0 g/mol (Contact for details)
Synonyms	(R)-3-[3-Acetyl-4-[3-[(1,1,2,2,3,3,4,4,4-nonadeuterio-2-hydroxypropyl)amino]-2-hydroxypropoxy]phenyl]-1,1-diethylurea Hydrochloride; Celiprolol-d9 HCl; [2H9]-Celiprolol Hydrochloride; (R)-(+)-1-(2-Acetyl-4-(2-hydroxy-3-((1,1,2,2,3,3,4,4,4-nonadeuterio-2-hydroxypropyl)amino)propoxy)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride; Deuterated Celiprolol Internal Standard
EINECS	Contact for details

Quality Control

Every batch of our (R)-(+)-Celiprolol-D9 Hydrochloride is manufactured and controlled to meet the exacting standards required for analytical reference materials. We employ advanced chromatographic and spectroscopic techniques to ensure high chemical and isotopic purity, critical for its performance as an internal standard. Comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are provided to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be kept in a cool, dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.