Description

Benoxaprofen-13C,D3 is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) Benoxaprofen, specifically enriched with carbon-13 and deuterium. This compound is an essential internal standard for the precise quantification and pharmacokinetic profiling of Benoxaprofen in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and bioanalytical studies to ensure data accuracy and regulatory compliance.

Application

• Bioanalytical Method Development and Validation: Serves as a critical internal standard for the accurate quantification of Benoxaprofen in plasma, serum, and other biological fluids.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Mass Spectrometry (LC-MS/MS) Calibration: Used to correct for instrument variability and matrix effects, ensuring highly reliable and reproducible analytical results.
• Drug Impurity Profiling and Degradation Studies: Assists in identifying and quantifying potential metabolites or degradation products of Benoxaprofen.
• Regulatory Submission Support: Provides the traceable reference material needed for studies compliant with FDA, EMA, and ICH guidelines.
• Stable Isotope Dilution Assays: Fundamental for high-precision assays where maximum accuracy in concentration measurement is paramount.

Basic Information

Product Name	Benoxaprofen-13C,D3
CAS No.	1329840-53-0
Molecular Formula	C15H9D3ClNO3 (with 13C labeling)
Molecular Weight	~311.7 g/mol (exact weight depends on labeling position)
Synonyms	2-(4-Chlorophenyl)-α-methyl-5-benzoxazoleacetic-13C,α,α,α-d3 acid; 2-[4-Chlorophenyl]-α-methyl-5-benzoxazoleacetic-13C,α,α,α-d3 acid; Benoxaprofen-(phenyl-13C6, methyl-d3); Isotopically labeled Benoxaprofen; [13C,D3]-Benoxaprofen; Benoxaprofen Internal Standard; Stable Isotope-Labeled Benoxaprofen
EINECS	Contact for details

Quality Control

Every batch of Benoxaprofen-13C,D3 is manufactured and analyzed under strict quality protocols to ensure exceptional isotopic and chemical purity, which is critical for its role as an analytical standard. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data including isotopic enrichment (atom % 13C and D), chemical purity by HPLC, and confirmation of structure by NMR and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive (store away from light). For long-term storage, keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % 13C)	≥99%
Isotopic Purity (Atom % D)	≥98%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.