Description

Althiazide-D5 is a deuterated analog of the thiazide diuretic Althiazide, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism, pharmacokinetic studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Althiazide in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of Althiazide.
• Bioanalytical Method Development: Used to validate and optimize high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) methods for regulatory compliance.
• Clinical Research: Enables accurate monitoring of drug concentration levels in patient samples during clinical trials.
• Forensic and Doping Control Analysis: Provides a reliable reference for detecting and quantifying the parent compound in specialized screening protocols.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry experiments.

Basic Information

Product Name	Althiazide-D5
CAS No.	1329837-71-9
Molecular Formula	C13H11D5ClN3O4S3
Molecular Weight	402.96 g/mol (for deuterated form)
Synonyms	6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-d5; 3-[(2,2,2-Trifluoroethylthio)methyl]-6-chloro-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide-d5; Deuterated Althiazide; Althiazide (phenyl-d5); Althiazide-d5 Internal Standard
EINECS	Contact for details

Quality Control

Our Althiazide-D5 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical stability required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (≥98 atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to cGMP guidelines for the production of reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.