Description

Thiorphan Methoxyacetophenone-13C,D3 Derivative is a high-purity, isotopically labeled chemical reference standard. This compound is critical for ensuring analytical accuracy and traceability in quantitative mass spectrometry, particularly for pharmacokinetic and metabolic studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring definitive internal standards for method development and validation.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of Thiorphan and related metabolites.
• Pharmaceutical Metabolism & Pharmacokinetics (DMPK): Enables precise measurement of drug concentration, absorption, distribution, and excretion in biological matrices.
• Bioanalytical Method Development: Serves as a critical component in developing and validating robust, sensitive, and specific analytical methods compliant with GLP/GCP guidelines.
• Clinical Research: Used in clinical trial sample analysis to ensure data integrity and regulatory compliance for new drug applications.
• Neutral Endopeptidase (NEP) Inhibitor Research: Supports advanced research into enzyme inhibition mechanisms and the development of related therapeutic agents.
• Certified Reference Material (CRM) Production: Serves as a high-grade starting material for the preparation of certified reference standards with guaranteed purity and isotopic enrichment.

Basic Information

Product Name	Thiorphan Methoxyacetophenone-13C,D3 Derivative
CAS No.	1329837-24-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-[(R,S)-2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine Methoxyacetophenone-13C,D3 Derivative; (RS)-N-(2-Mercaptomethyl-1-oxo-3-phenylpropyl)glycine Methoxyacetophenone-13C,D3 Derivative; Isotopically Labeled Thiorphan Derivative; 13C/D3-Thiorphan Methoxyacetophenone Derivative; Stable Isotope-Labeled Thiorphan Standard; [13C,D3]-Thiorphan Methoxyacetophenone
EINECS	Contact for details

Quality Control

Every batch of our Thiorphan Methoxyacetophenone-13C,D3 Derivative is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity verified by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity (HPLC assay), isotopic enrichment, and residual solvents. Our quality commitment ensures consistency and reliability for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Isotopic Enrichment	≥99 atom % 13C; ≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.