Description

Decloxizine-D8 Dihydrochloride is a deuterated, high-purity chemical reference standard essential for advanced analytical and research applications. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring precise internal standards for method development and validation.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and GC-MS bioanalytical methods.
• Quantitative analysis and pharmacokinetic (PK) studies of the parent drug, Decloxizine, in biological matrices (plasma, serum, urine).
• Metabolite identification and drug metabolism studies in pharmaceutical research and development.
• Method development, validation, and quality control in analytical laboratories to ensure data integrity and regulatory compliance.
• Use in clinical research for accurate therapeutic drug monitoring (TDM).
• Supporting regulatory submissions (e.g., to FDA, EMA) by providing definitive analytical data.

Basic Information

Product Name	Decloxizine-D8 Dihydrochloride
CAS No.	1329836-11-4
Molecular Formula	C18H14D8Cl2N2O • 2HCl
Molecular Weight	~ 424.2 g/mol (Contact for exact details)
Synonyms	1-(Diphenylmethyl)-4-[(2,3,4,5,6,7,8,8-octadeuterio-3-methyl-2-buten-1-yl)oxy]piperazine Dihydrochloride; Decloxizine-d8 Dihydrochloride; Deuterated Decloxizine Dihydrochloride; Decloxizine (D8) 2HCl; 1-(Benzhydryl)-4-[(3-methylbut-2-en-1-yl-d8)oxy]piperazine Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of Decloxizine-D8 Dihydrochloride is manufactured and tested under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to confirm chemical identity, purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.