Description

Rac 3-Deacetyl-3-Butanoyl Acebutolol-D5 Hydrochloride is a high-purity, isotopically labeled internal standard critical for advanced analytical quantification. This compound is essential for ensuring the accuracy and reliability of mass spectrometry-based methods in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research (CRO), and forensic toxicology laboratories for precise pharmacokinetic studies, metabolism investigations, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a deuterated internal standard for the accurate quantification of acebutolol and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables precise measurement of drug concentration over time, critical for determining absorption, distribution, metabolism, and excretion (ADME) profiles.
• Metabolite Profiling and Identification: Aids in the detection and structural elucidation of drug metabolites during metabolism studies.
• Method Development and Validation: Serves as a key component in developing and validating robust, GLP-compliant bioanalytical assays.
• Forensic and Clinical Toxicology: Supports the accurate screening and confirmation of acebutolol in forensic investigations and clinical overdose cases.
• Quality Control in Pharmaceutical Manufacturing: Used in quality control laboratories to monitor potential impurities or degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Rac 3-Deacetyl-3-Butanoyl Acebutolol-D5 Hydrochloride
CAS No.	1329836-09-0
Molecular Formula	C20H30D5ClN2O5
Molecular Weight	Contact for details
Synonyms	Acebutolol D5 Butanoyl Derivative Hydrochloride; 3'-Deacetyl-3'-(1-oxobutyl)acebutolol-D5 HCl; N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide-D5 Hydrochloride; Acebutolol-d5 Metabolite Standard; (±)-3'-Deacetyl-3'-(butanoyl)acebutolol-d5 hydrochloride; Acebutolol D5 Internal Standard; 1-(2-Acetyl-4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-3-methylbutan-1-one-d5 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Rac 3-Deacetyl-3-Butanoyl Acebutolol-D5 Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.