Description

Mexiletine D6 is a deuterated analog of the Class IB antiarrhythmic agent Mexiletine, specifically labeled with six deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers engaged in drug development and therapeutic monitoring.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise measurement of Mexiletine in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the parent drug and its metabolites, improving data accuracy by correcting for instrument variability and sample preparation losses.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables accurate quantification of Mexiletine levels in patient samples to optimize dosing regimens and ensure therapeutic efficacy while minimizing side effects.
• Pharmaceutical Quality Control: Supports analytical method development and validation for drug substance and drug product testing in compliance with regulatory guidelines (e.g., FDA, ICH).
• Forensic and Toxicology Analysis: Facilitates the reliable detection and quantification of Mexiletine in forensic investigations or cases of suspected overdose.

Basic Information

Product Name	Mexiletine D6
CAS No.	1329835-60-0
Molecular Formula	C11H11D6NO
Molecular Weight	185.28 g/mol
Synonyms	1-(2,6-Dimethylphenoxy)-2-propanamine-d6; (RS)-1-(2,6-Dimethylphenoxy)-2-aminopropane-d6; 2,6-Dimethylphenoxyisopropylamine-d6; Mexiletine-d6; Mexitil-d6; 1-(2,6-Xyloxy)-2-propylamine-d6; DL-Mexiletine-d6; KMX-d6
EINECS	Contact for details

Quality Control

Our Mexiletine D6 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D6, min. 99 atom % D), chemical purity (by HPLC, typically ≥98%), and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled compounds, and our quality commitment ensures reliable performance as a critical reference material in your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 99 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.