Description

Rac Des(Isopropylamino) Acebutolol-D5 Diol is a deuterated analog of a key acebutolol intermediate, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring accurate quantification and method validation in sensitive analytical techniques. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards for pharmacokinetic studies, metabolism research, and quality control of active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the precise quantification of acebutolol and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D and Metabolism Studies: Used in drug discovery and development to track the pharmacokinetic profile and metabolic pathways of acebutolol.
• Bioanalytical Method Development and Validation: Serves as a critical component in establishing robust, accurate, and reproducible analytical methods compliant with GLP/GMP guidelines.
• Manufacturing of Certified Reference Materials (CRMs): Acts as a starting material for producing high-grade reference standards for regulatory submission and quality assurance.
• Impurity Profiling and Characterization: Aids in the identification and quantification of process-related impurities and degradation products in acebutolol API batches.

Basic Information

Product Name	Rac Des(Isopropylamino) Acebutolol-D5 Diol
CAS No.	1329835-55-3
Molecular Formula	C14H17D5N2O3
Molecular Weight	267.36 g/mol (approx.)
Synonyms	Desisopropyl Acebutolol-D5 Diol; Acebutolol D5 Diol Impurity; 3'-Amino-4'-(2-hydroxy-3-[(1-methylethyl)amino]propoxy)butyrophenone-D5 Diol; 1-(4-{2-Hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)-3-(methylamino)propan-1-one-D5 Diol; Acebutolol Desisopropyl D5 Diol; Acebutolol Impurity D (D5); Acebutolol Related Compound D D5
EINECS	Contact for details

Quality Control

Every batch of Rac Des(Isopropylamino) Acebutolol-D5 Diol is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality commitment includes comprehensive characterization by NMR (1H, 13C), HPLC, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as chemical purity, isotopic purity (D5 content), and residual solvent levels to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.