Description

Desmethyl Ranolazine-D5 is a deuterium-labeled analog of a key ranolazine metabolite, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and precision in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug development and bioanalytical testing.

Application

• Bioanalytical Method Development and Validation: Serves as a critical internal standard for the accurate quantification of desmethyl ranolazine in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables precise tracking of metabolite levels to understand drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Drug Metabolism and Disposition Research: Used in in vitro and in vivo studies to elucidate the metabolic pathways of ranolazine and assess drug-drug interaction potentials.
• Clinical Trial Support: Provides reliable data for bioequivalence studies and therapeutic drug monitoring during clinical phases of drug development.
• Quality Control in Pharmaceutical Analysis: Supports method transfer and routine quality control testing in GLP/GMP-compliant laboratories.

Basic Information

Product Name	Desmethyl Ranolazine-D5
CAS No.	1329834-18-5
Molecular Formula	C23H28D5N3O4
Molecular Weight	~ 414.55 g/mol
Synonyms	N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxy-2H-1,2,3,4-tetrazol-5-yl)propoxy]phenyl]acetamide-d5; Ranolazine Metabolite OPC-14714-D5; (±)-N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxy-2H-1,2,3,4-tetrazol-5-yl)propoxy]phenethylacetamide-d5; Desmethyl Ranolazine d5; 1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine-d5 (deuterated form)
EINECS	Contact for details

Quality Control

Our Desmethyl Ranolazine-D5 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D-enrichment), and identity confirmation. We adhere to relevant industry standards to support research in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.