Description

9-Defluoro-9-(4-Methyl-1-Piperazinyl) Levofloxacin is a key pharmaceutical intermediate and a structural analog of the broad-spectrum fluoroquinolone antibiotic, levofloxacin. This compound is of significant value for research and development in medicinal chemistry, particularly for synthesizing novel antibacterial agents and studying structure-activity relationships. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) seeking to develop or produce next-generation antibiotic compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel fluoroquinolone antibiotic derivatives and prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to understand the impact of fluorine substitution and piperazinyl modifications on antibacterial efficacy and pharmacokinetics.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the development and scale-up production of new antibacterial APIs.
• Biochemical Research: Employed as a tool compound to investigate bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Product Name	9-Defluoro-9-(4-Methyl-1-Piperazinyl) Levofloxacin
CAS No.	1329833-82-0
Molecular Formula	C21H28FN5O4
Molecular Weight	433.48 g/mol
Synonyms	9-Desfluoro-9-(4-methylpiperazin-1-yl)levofloxacin; Levofloxacin 9-(4-methylpiperazine) analog; (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid derivative; 9-DeF-9-(4-Me-Pip) Levofloxacin; 9-(4-Methylpiperazin-1-yl)levofloxacin desfluoro analog; 1329833-82-0; 9-DF-9-(4-MP) Levofloxacin
EINECS	Contact for details

Quality Control

Our 9-Defluoro-9-(4-Methyl-1-Piperazinyl) Levofloxacin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, it should be handled in a dry environment and the container kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.