Description

Etoperidone-D8 Hydrochloride is a deuterated isotopologue of the antidepressant compound Etoperidone, specifically labeled with eight deuterium atoms. This high-purity reference standard is essential for ensuring accuracy and reliability in quantitative analytical methods. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic, metabolic, and bioanalytical studies.

Application

• Primary use as an Internal Standard for the precise quantification of Etoperidone in complex biological matrices via LC-MS/MS and GC-MS.
• Critical component in Drug Metabolism and Pharmacokinetics (DMPK) studies to investigate absorption, distribution, metabolism, and excretion (ADME) profiles.
• Essential for conducting Bioequivalence and Bioavailability studies in clinical research and generic drug development.
• Used in Forensic and Clinical Toxicology for the accurate identification and measurement of Etoperidone.
• Supports Pharmaceutical Quality Control and method validation processes in manufacturing environments.
• Valuable research tool in Neuroscience and Pharmacology for studying the mechanism of action of serotonin antagonist and reuptake inhibitors (SARIs).

Basic Information

Product Name	Etoperidone-D8 Hydrochloride
CAS No.	1329796-60-2
Molecular Formula	C19H14D8N3O•HCl
Molecular Weight	357.89 g/mol
Synonyms	1-[3-[2-(3-Chlorophenyl)-1-piperazinyl]propyl]-3,4,5,6,7,8-hexahydro-2H-1,3,8,8-d4-azepino[4,5-b]indol-2-one-d4 Hydrochloride; Etoperidone (phenyl-d5, piperazine-d3) Hydrochloride; Deuterated Etoperidone HCl; Etoperidone-d8 HCl; Nefiran-d8 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Etoperidone-D8 Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and all relevant specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.