Description

1,4-Bis(Benzhydryl)Piperazine-D8 Dihydrochloride is a high-purity, deuterated derivative of a key pharmaceutical intermediate. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is an essential material for research and development laboratories in the pharmaceutical and biotechnology sectors, particularly those focused on analytical method development and drug metabolism and pharmacokinetics (DMPK).

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of its non-deuterated counterpart in biological matrices.
• Pharmaceutical R&D: Critical for method development and validation in drug discovery and development pipelines.
• Metabolite Identification & Pharmacokinetics: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies.
• Bioanalytical Assay Development: Used to develop robust, sensitive, and specific assays for clinical and pre-clinical trials.
• Reference Material: Serves as a certified reference material (CRM) for quality control and assurance in analytical laboratories.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy analytical techniques requiring minimal matrix effects.

Basic Information

Product Name	1,4-Bis(Benzhydryl)Piperazine-D8 Dihydrochloride
CAS No.	1329634-36-7
Molecular Formula	C30H22D8Cl2N2
Molecular Weight	Contact for details
Synonyms	1,4-Bis(diphenylmethyl)piperazine-d8 dihydrochloride; 1,4-Bis(benzhydryl)piperazine-2,2,3,3,5,5,6,6-d8 dihydrochloride; Piperazine, 1,4-bis(diphenylmethyl)-, octadeuterated, dihydrochloride; Deuterated 1,4-Bis(benzhydryl)piperazine dihydrochloride; D8-1,4-Bis(Benzhydryl)Piperazine 2HCl; Bis-Bnz-Pip-d8 2HCl
EINECS	Contact for details

Quality Control

Our 1,4-Bis(Benzhydryl)Piperazine-D8 Dihydrochloride is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (HPLC), isotopic purity (NMR/MS), and impurity profile. We adhere to relevant industry standards for research chemicals and can provide material tailored to your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.