Description

(S)-(+)-Camptothecin-D5 is a deuterium-labeled analog of the potent topoisomerase I inhibitor, camptothecin. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring precise and accurate measurement of camptothecin and its derivatives in complex biological matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, particularly those involved in the development, pharmacokinetic study, and therapeutic drug monitoring of camptothecin-based anticancer agents.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity internal standard for the quantitative analysis of camptothecin, irinotecan, topotecan, and related metabolites in plasma, serum, and tissue samples via liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Pharmacokinetic and Metabolite Studies: Enables accurate determination of drug concentration-time profiles, bioavailability, clearance rates, and metabolite identification in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing robust, sensitive, and regulatory-compliant (FDA, EMA) analytical methods for drug development pipelines.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of the parent drug molecule with high specificity.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation for active pharmaceutical ingredients (APIs) and finished drug products containing camptothecin analogs.
• Biomarker Research: Facilitates the precise quantification of camptothecin levels in biomarker discovery and validation studies related to oncology therapeutics.

Basic Information

Product Name	(S)-(+)-Camptothecin-D5
CAS No.	1329616-37-6
Molecular Formula	C20H11D5N2O4
Molecular Weight	349.38 g/mol
Synonyms	(S)-Camptothecin-d5; (+)-Camptothecin-d5; Camptothecin (ring-D5, (S)-); 4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione-d5; (19S)-19,20-Didehydro-10,11-methylenedioxycamptothecin-d5; CPT-d5; Stable Isotope Labeled Camptothecin; Camptothecin Internal Standard
EINECS	Contact for details

Quality Control

Our (S)-(+)-Camptothecin-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm structure, isotopic enrichment, and purity. Certificates of Analysis (COA) are provided, detailing batch-specific results for identity, assay, isotopic purity, and related substances. Our quality commitment supports compliance with relevant guidelines for reference standards used in pharmaceutical analysis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Isotopic Enrichment (by MS)	≥ 95% D5
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.