Description

Domperidone-D6 is a deuterated isotopologue of the dopamine D2 receptor antagonist, Domperidone, where six hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology requiring precise pharmacokinetic and metabolic studies.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of Domperidone.
• Metabolite identification and drug metabolism and pharmacokinetics (DMPK) studies in pharmaceutical R&D.
• Bioanalytical method development and validation for clinical trial sample analysis.
• Forensic and anti-doping analysis for the accurate detection of Domperidone in biological matrices.
• Use in stable isotope dilution assays to correct for analyte loss during sample preparation.
• Research applications in neurogastroenterology and pharmacology involving dopamine receptor studies.

Basic Information

Product Name	Domperidone-D6
CAS No.	1329614-18-7
Molecular Formula	C22H18D6ClN5O2
Molecular Weight	429.94 g/mol (deuterated form)
Synonyms	5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one-d6; Domperidone (hexadeuterated); Domperidone-d6; [2H6]-Domperidone; 1H-Benzimidazol-2-one, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, labeled with deuterium; Motilium-d6 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Domperidone-D6 is manufactured and analyzed under strict quality control protocols to ensure exceptional isotopic purity and chemical purity suitable for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity (by HPLC), and identity confirmation (by NMR and MS) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.