Description

Rac n-Desbutyroyl-D5 Acebutolol CAS NO 1329613-82-2 is a high-purity, deuterated analog of a key pharmaceutical intermediate, specifically designed for advanced research and development. This compound is essential for use as an internal standard in mass spectrometry-based analytical methods, ensuring precise quantification and reliable data in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on cardiovascular drug development and bioanalytical method validation.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS bioanalysis for acebutolol and related metabolites.
• Critical component in deuterium-labeled reference material synthesis for pharmaceutical research.
• Supporting drug metabolism and pharmacokinetics (DMPK) studies to understand the disposition of β-blocker drugs.
• Enabling high-accuracy quantitative analysis in clinical and pre-clinical trial samples.
• Used in the development and validation of regulatory-compliant analytical methods for drug substance and product testing.
• Research applications in isotope dilution mass spectrometry to achieve superior analytical precision.

Basic Information

Product Name	Rac n-Desbutyroyl-D5 Acebutolol
CAS No.	1329613-82-2
Molecular Formula	C14H17D5N2O3
Molecular Weight	Contact for details
Synonyms	3'-Acetamido-4'-[2-hydroxy-3-(isopropylamino)propoxy]butyrophenone-d5; Acebutolol Desbutyroyl Metabolite-d5; N-Desbutyryl Acebutolol-d5; Acebutolol-d5 Diacetolol; (±)-Diacetolol-d5; 1-(2-Acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)ethanone-d5; Rac-Diacetolol-d5
EINECS	Contact for details

Quality Control

Every batch of Rac n-Desbutyroyl-D5 Acebutolol is manufactured and controlled under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles, typically determined by advanced techniques including NMR, HPLC, and Mass Spectrometry. Our quality commitment ensures the material meets the exacting standards required for sensitive analytical applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.