Description

(S)-(-)-Verapamil-D6 Hydrochloride is a high-purity, deuterium-labeled isotopologue of the classic calcium channel blocker, verapamil. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories focused on cardiovascular drug development and drug metabolism research.

Application

• LC-MS/MS Internal Standard: Primary application as a stable, isotopically labeled internal standard for the precise quantification of verapamil and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Research: Used in in vitro and in vivo studies to investigate metabolic pathways, enzyme kinetics, and potential drug-drug interactions.
• Bioanalytical Method Development & Validation: Critical for developing robust, regulatory-compliant (FDA, EMA) analytical methods for bioequivalence and therapeutic drug monitoring studies.
• Reference Material for Certified Standards: Serves as a high-purity certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity.

Basic Information

Item	Details
Product Name	(S)-(-)-Verapamil-D6 Hydrochloride
CAS No.	1329611-24-6
Molecular Formula	C27H32D6ClN2O4 • HCl
Molecular Weight	~ 507.1 g/mol
Synonyms	Verapamil-d6 HCl; (S)-Verapamil-d6 hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile-d6 hydrochloride; (2S)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(1-methylethyl)pentanenitrile-d6 hydrochloride; Isoptin-d6 HCl; (±)-Verapamil-d6 hydrochloride (S-isomer); Deuterated Verapamil Internal Standard
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-Verapamil-D6 Hydrochloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization including NMR, HPLC, and mass spectrometry to confirm structure, purity, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment supports compliance with ICH Q7 and GMP guidelines for materials intended for use in regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.