Description

Rac n-Desisopropyl-n-Ethyl Acebutolol-D5 is a deuterated analog of the β-blocker acebutolol, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities that require precise measurement of acebutolol and its metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the quantification of acebutolol in bioanalytical methods, ensuring method robustness and compensating for matrix effects and instrument variability.
• Pharmaceutical Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track and quantify the parent drug and its metabolites, aiding in the understanding of drug clearance pathways.
• Clinical Trial Support: Critical for generating reliable pharmacokinetic data in human and animal clinical trials, supporting new drug applications (NDAs) and regulatory submissions.
• Forensic and Doping Analysis: Employed in specialized testing laboratories for the precise detection and quantification of acebutolol in forensic toxicology or anti-doping control samples.
• Method Development and Validation: Serves as a key reagent during the development, optimization, and validation of sensitive and selective analytical assays in compliance with FDA, EMA, and ICH guidelines.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and stability-indicating methods to monitor the quality of acebutolol active pharmaceutical ingredient (API) during production.

Basic Information

Product Name	Rac n-Desisopropyl-n-Ethyl Acebutolol-D5
CAS No.	1329512-38-0
Molecular Formula	C16H20D5N2O4
Molecular Weight	Contact for details
Synonyms	rac n-Desisopropyl-n-ethyl Acebutolol-d5; Acebutolol-d5 (n-Desisopropyl-n-Ethyl); 3'-Acetyl-4'-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]butyranilide-d5 (n-Desisopropyl-n-Ethyl); (±)-n-Desisopropyl-n-ethyl Acebutolol-d5; Deuterated Acebutolol Internal Standard; Acebutolol D5 Isomer; [2H5]-Acebutolol (n-Desisopropyl-n-Ethyl); Acebutolol-d5 Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of Rac n-Desisopropyl-n-Ethyl Acebutolol-D5 is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for isotopic purity and chemical identity. Certificates of Analysis (COA) are available upon request, providing detailed results for key parameters such as assay, isotopic enrichment, and purity by HPLC and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.