Description

(R)-(-)-Ketoprofen-13C,D3 is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) Ketoprofen, specifically enriched with carbon-13 and deuterium. This compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and mass spectrometry-based assays.

Application

• Primary use as an Internal Standard (IS) for the accurate quantification of Ketoprofen in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• Critical Reference Material for method development, validation, and quality control in bioanalytical laboratories.
• Essential tool in Pharmacokinetic (PK) and Drug Metabolism (DMPK) studies to track the absorption, distribution, metabolism, and excretion of Ketoprofen.
• Used in Stable Isotope Dilution Assays (SIDA) to achieve high precision and accuracy in analytical measurements.
• Supports research into enantioselective metabolism and the specific biological activity of the (R)-enantiomer of Ketoprofen.
• Application in Forensic and Clinical Toxicology for the definitive identification and measurement of Ketoprofen.

Basic Information

Product Name	(R)-(-)-Ketoprofen-13C,D3
CAS No.	1329496-52-7
Molecular Formula	C1613CH11D3O3
Molecular Weight	~258.31 g/mol
Synonyms	(R)-2-(3-Benzoylphenyl)propionic-13C,3,3,3-d3 acid; (R)-Ketoprofen-13C,d3; (R)-(-)-3-Benzoyl-α-methylbenzeneacetic-13C,3,3,3-d3 acid; Dexketoprofen-13C,d3; (R)-Ketoprofen (phenyl-13C6, 3,3,3-d3); Stable Isotope Labeled (R)-Ketoprofen; (R)-Ketoprofen Internal Standard; (2R)-2-[3-(Benzoyl)phenyl]propanoic-13C,3,3,3-d3 acid
EINECS	Contact for details

Quality Control

Every batch of (R)-(-)-Ketoprofen-13C,D3 is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure high chemical purity, isotopic enrichment, and chiral purity, meeting the exacting standards required for analytical reference materials. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic purity, enantiomeric excess, and identification. Our quality commitment supports compliance with GMP/GLP principles for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to labeled structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C; ≥ 98 atom % D
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.