Description

O6-(2-Hydroxypropyl)-2'-Deoxyguanosine is a chemically modified nucleoside analog, specifically an alkylated derivative of 2'-deoxyguanosine. This compound is of significant value in biochemical and pharmacological research, serving as a critical tool for studying DNA alkylation damage, repair mechanisms, and mutagenesis. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on oncology, toxicology, and molecular biology applications.

Application

• Biomarker Research: Used as a reference standard for the detection and quantification of specific DNA adducts in studies of chemical carcinogenesis and genotoxicity.
• Mechanistic Studies: Essential for investigating the enzymatic activity and specificity of DNA repair enzymes, such as O6-alkylguanine-DNA alkyltransferase (AGT).
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the development of chemotherapeutic agents and drugs targeting DNA repair pathways.
• Toxicology & Safety Assessment: Employed in in vitro and in vivo models to assess the biological impact of alkylating agents and environmental toxins.
• Diagnostic Kit Manufacturing: Used in the production of calibration standards for diagnostic assays measuring DNA damage and repair capacity.
• Academic Research: A fundamental reagent for university and institutional labs studying nucleic acid chemistry, structural biology, and cancer biology.

Basic Information

Product Name	O6-(2-Hydroxypropyl)-2'-Deoxyguanosine
CAS No.	1327339-22-9
Molecular Formula	C13H19N5O5
Molecular Weight	325.32 g/mol
Synonyms	O6-(2-Hydroxypropyl)deoxyguanosine; 2'-Deoxy-O6-(2-hydroxypropyl)guanosine; O6-HPG-dG; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[(2-hydroxypropyl)amino]-1H-purin-2-one; O6-(2-Hydroxypropyl)-2'-deoxy-Guanosine; Alkylated 2'-Deoxyguanosine Derivative; DNA Alkylation Adduct Standard
EINECS	Contact for details

Quality Control

Our O6-(2-Hydroxypropyl)-2'-Deoxyguanosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and water content analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.