Description

Niclosamide-13C6 Hydrate (See Data Sheet) is a stable isotope-labeled analog of the anthelmintic drug Niclosamide, where six carbon atoms are replaced with the 13C isotope. This compound is essential as an internal standard for the precise quantification of Niclosamide in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental monitoring sectors who require high-fidelity data for method development, pharmacokinetic studies, and regulatory compliance. The product is supplied with a comprehensive data sheet detailing its specifications.

Application

• Internal Standard for Mass Spectrometry: Primary use as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for accurate bioanalysis.
• Pharmaceutical Research & Development: Enables precise pharmacokinetic (PK) and pharmacodynamic (PD) studies of Niclosamide and its formulations.
• Metabolite Identification & Profiling: Aids in the detection and structural elucidation of Niclosamide metabolites in in vitro and in vivo studies.
• Regulatory Compliance & Method Validation: Supports the development and validation of GLP/GMP-compliant analytical methods for regulatory submissions.
• Environmental & Residue Analysis: Used in monitoring Niclosamide residues in environmental samples, food, or agricultural products.
• Clinical Diagnostics & Toxicology: Facilitates accurate measurement of Niclosamide levels in clinical or forensic toxicology applications.

Basic Information

Product Name	Niclosamide-13C6 Hydrate (See Data Sheet)
CAS No.	1325808-64-7
Molecular Formula	C13C6H8Cl2N2O4 • xH2O
Molecular Weight	~339.1 (anhydrous free acid basis)
Synonyms	2',5-Dichloro-4'-nitrosalicylanilide-13C6; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide-13C6; 5-Chlorosalicyl-(2-chloro-4-nitro)anilide-13C6; Bayluscid-13C6; Yomesan-13C6; Clonitralid-13C6; IUPAC: 5-Chloro-2-hydroxy-N-(2-chloro-4-nitrophenyl)benzamide-13C6
EINECS	Contact for details

Quality Control

Every batch of Niclosamide-13C6 Hydrate is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for trace analytical applications. Our quality commitment includes comprehensive testing against stringent specifications for isotopic enrichment, chemical purity, and identity. A Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic purity, and related substances. We support compliance with GMP/GLP guidelines for research and regulatory purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to yellow-brown crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity	≥99 atom % 13C
Isotopic Enrichment	≥99% on 13C6 position
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.