Description

Mefenamic Acid-13C6 CAS NO 1325559-19-0 is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) mefenamic acid, where six carbon atoms are replaced with the 13C isotope. This compound is an essential internal standard for the precise and accurate quantification of mefenamic acid in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research. The use of this isotopically labeled standard is critical for ensuring data integrity and regulatory compliance in quantitative bioanalysis.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the LC-MS/MS quantification of mefenamic acid in plasma, serum, and urine for pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of mefenamic acid.
• Clinical Research: Enables accurate measurement of drug concentrations in patient samples during clinical trials for bioequivalence and therapeutic drug monitoring.
• Forensic and Anti-Doping Analysis: Provides a reliable reference standard for the confirmatory analysis of mefenamic acid in forensic toxicology and sports doping control.
• Pharmaceutical Quality Control: Can be utilized in method development and validation for the assay and impurity profiling of mefenamic acid in drug substances and products.
• Environmental and Food Safety Testing: Applicable in trace analysis methods for detecting pharmaceutical residues in environmental water samples or food products.

Basic Information

Product Name	Mefenamic Acid-13C6
CAS No.	1325559-19-0
Molecular Formula	13C6C9H11NO2
Molecular Weight	~247.2 g/mol (based on 13C substitution)
Synonyms	2-[(2,3-Dimethylphenyl)amino]-13C6-benzoic acid; Ponstel-13C6; Mefenamic Acid (13C6); Mefenamic Acid-13C6 (six 13C labeled); 13C6-Mefenamic Acid; N-(2,3-Dimethylphenyl)anthranilic acid-13C6; 2-[(2,3-Xylyl)amino]-13C6-benzoic acid
EINECS	Contact for details

Quality Control

Our Mefenamic Acid-13C6 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical identity, which are critical for its use as a mass spectrometry internal standard. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and LC-MS, to confirm isotopic enrichment, chemical purity, and absence of unlabeled material. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic purity (atom % 13C), chemical purity (by HPLC), and spectroscopic confirmation. Our quality system supports compliance with the rigorous demands of GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled and stored accordingly to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % 13C)	≥99% on the labeled positions
Isotopic Enrichment (LC-MS)	≥98% (M+6)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.