Description

Niclosamide-13C6 is a stable isotope-labeled analog of the anthelmintic agent Niclosamide, where six carbon atoms are replaced with the 13C isotope. This compound is essential as an internal standard for the precise and accurate quantification of Niclosamide in complex matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, environmental monitoring, and agrochemical sectors, ensuring data integrity in method development, pharmacokinetic studies, and regulatory compliance testing.

Application

• Quantitative Analytical Internal Standard: Primary use as a certified reference material for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of Niclosamide.
• Pharmaceutical Research & Development: Enables accurate pharmacokinetic, metabolic, and bioequivalence studies of Niclosamide and its formulations.
• Environmental and Food Safety Testing: Used in the detection and quantification of Niclosamide residues in water, soil, and agricultural products to monitor environmental impact and ensure food safety compliance.
• Clinical Diagnostics and Toxicology: Supports the development of high-precision diagnostic assays for therapeutic drug monitoring and forensic toxicology investigations.
• Method Validation and Quality Assurance: Critical for validating analytical methods according to ICH, FDA, and EMA guidelines in GMP/GLP-compliant laboratories.
• Biomedical Research: Facilitates studies exploring the novel therapeutic potentials of Niclosamide, such as in cancer research and antiviral studies, by providing a reliable isotopic tracer.

Basic Information

Product Name	Niclosamide-13C6
CAS No.	1325559-12-3
Molecular Formula	C7H5Cl213C6N2O4
Molecular Weight	~335.1 g/mol (for 13C6 labeled form)
Synonyms	2',5-Dichloro-4'-nitrosalicylanilide-13C6; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide-13C6; Yomesan-13C6; Bayluscid-13C6; Clonitralid-13C6; 5-Chloro-2'-chloro-4'-nitrosalicylanilide-13C6; [13C6]-Niclosamide
EINECS	Contact for details

Quality Control

Every batch of Niclosamide-13C6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for identity, purity (HPLC), isotopic enrichment, and residual solvents. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular ion and fragmentation pattern
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 99 atom % 13C (for labeled positions)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.