Description

3,4-Di-o-Benzyl Droxidopa-13C2,15N Hydrochloride (Mixture Of Diastereomers) is a high-purity, isotopically labeled derivative of droxidopa, a synthetic amino acid precursor to norepinephrine. This compound is specifically designed for use as a critical reference standard and an advanced intermediate in pharmaceutical research and development. It is essential for scientists in the fields of pharmacology, analytical chemistry, and drug metabolism, enabling precise quantitative analysis, method validation, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the accurate quantification of droxidopa and its metabolites in complex biological matrices using LC-MS/MS and other analytical techniques.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Utilized in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of droxidopa, providing critical data for drug development.
• Isotope-Labeled Intermediate: Acts as a key building block in the synthesis of more complex, isotopically labeled drug candidates or metabolites for advanced research applications.
• Analytical Method Development: Employed to develop, validate, and calibrate highly sensitive and specific analytical methods in compliance with GLP and GMP guidelines.
• Clinical Research: Supports clinical trial studies requiring precise tracking and measurement of drug levels, enhancing the reliability of pharmacokinetic data.
• Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Item	Details
Product Name	3,4-Di-o-Benzyl Droxidopa-13C2,15N Hydrochloride (Mixture Of Diastereomers)
CAS No.	1323255-72-6
Molecular Formula	C20H2213C215NO5 • HCl
Molecular Weight	Contact for details
Synonyms	L-DOPS-13C2,15N Di-O-Benzyl Ester Hydrochloride; (2S)-2-Amino-3-(3,4-bis(benzyloxy)phenyl)-3-13C2,15N-propanoic Acid Hydrochloride; Droxidopa-13C2,15N Di-O-Benzyl Ester HCl; Isotopically Labeled Droxidopa Intermediate; 3,4-Di-O-Benzyl-L-DOPS-13C2,15N Hydrochloride; 3-(3,4-Bis(benzyloxy)phenyl)-L-serine-13C2,15N Di-O-Benzyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3,4-Di-o-Benzyl Droxidopa-13C2,15N Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet stringent specifications. Our quality assurance protocol is designed to support GLP and cGMP-compliant research. Comprehensive Certificates of Analysis (COA) detailing results for assay, isotopic purity, chiral purity, and related substances are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C; ≥99 atom % 15N
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.