Description

Tau Peptide (74-102) (Exon 3/Insert 2 Domain) is a synthetic peptide fragment corresponding to a specific region of the human microtubule-associated protein tau. This high-purity research-grade peptide is critical for studying tau protein biochemistry, aggregation mechanisms, and the molecular pathology of neurodegenerative diseases. It is an essential tool for academic researchers, pharmaceutical R&D teams, and diagnostic developers focused on Alzheimer's disease and related tauopathies.

Application

• Biochemical Research: Used as a substrate or antigen in studies investigating tau protein function, phosphorylation, and interaction with microtubules.
• Antibody Development & Validation: Serves as a key immunogen or capture antigen for generating and characterizing tau-specific antibodies, particularly those targeting the Exon 3/Insert 2 domain.
• Neurodegenerative Disease Modeling: Employed in in vitro aggregation assays to study the formation of tau oligomers and fibrils, mimicking pathological processes in Alzheimer's disease.
• Diagnostic Assay Development: Utilized in the calibration and quality control of ELISA, Western blot, and other immunoassays designed to detect tau species in biological samples.
• Drug Discovery Screening: Acts as a target in high-throughput screens to identify potential therapeutic compounds that inhibit tau aggregation or modify its pathological interactions.
• Structural Biology Studies: Provides a defined peptide sequence for NMR, X-ray crystallography, or cryo-EM studies to elucidate the structure of specific tau domains.

Basic Information

Product Name	Tau Peptide (74-102) (Exon 3/Insert 2 Domain)
CAS No.	1322695-34-0
Molecular Formula	C140H226N40O43S
Molecular Weight	3173.6 g/mol
Synonyms	Tau Protein Fragment 74-102; Human Tau (74-102); Microtubule-Associated Protein Tau (74-102); Tau Peptide Exon 3 Insert 2; MAPT (74-102); 2N4R Tau Peptide Fragment (74-102); Alzheimer's Disease Tau Peptide; pGlu-74-Tau-102
EINECS	Contact for details

Quality Control

Every batch of Tau Peptide (74-102) (Exon 3/Insert 2 Domain) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide full analytical data, including purity by HPLC, mass spectrometry confirmation, and endotoxin levels.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Amino Acid Sequence	H-Gln-Asp-Val-Gln-Ser-Lys-Val-Asp-Val-Lys-Ser-Lys-Val-Glu-Val-Gly-Ser-Lys-Gly-Asp-Ser-Thr-Lys-Ser-Thr-Pro-Ser-OH
Solubility	Soluble in water or dilute aqueous acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.