Description

Lopinavir-D8 is a deuterated isotopologue of the antiretroviral drug Lopinavir, where eight hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen. This stable-labeled compound is an essential internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of antiviral therapeutics.

Application

• Bioanalytical Internal Standard: Serves as a critical reference standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Lopinavir in biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Pharmaceutical Quality Control: Used in method development and validation to ensure the specificity and accuracy of assays for active pharmaceutical ingredient (API) and finished drug product testing.
• Clinical Research Support: Facilitates reliable therapeutic drug monitoring (TDM) in patient studies to correlate drug exposure with efficacy and safety outcomes.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques to minimize matrix effects and improve data reproducibility.

Basic Information

Product Name	Lopinavir-D8
CAS No.	1322625-54-6
Molecular Formula	C₃₇H₄₀D₈N₄O₅
Molecular Weight	~ 648.86 g/mol
Synonyms	Lopinavir (D8); Lopinavir-d8; ABT-378-d8; (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-2-(2,2,3,3,4,4,5,5-octadeuteriohexan-2-yl)amino]hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; Deuterated Lopinavir; LPV-d8
EINECS	Contact for details

Quality Control

Our Lopinavir-D8 is manufactured under strict quality systems to ensure it meets the exacting requirements for use as an analytical reference standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and chromatographic data. We adhere to relevant industry guidelines to guarantee consistency, traceability, and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.