Description

n-Biotinylcaproylaminocaproylaminocaproylaminoethyl Methanethiosulfonate is a specialized, high-purity biochemical reagent designed for advanced bioconjugation and labeling applications. This compound is engineered to provide a cleavable, sulfhydryl-reactive linker with an extended spacer arm and biotin tag, enabling precise protein modification and subsequent purification or detection via streptavidin-biotin interactions. It is an essential tool for researchers and developers in pharmaceutical R&D, proteomics, and diagnostic assay development who require reliable and site-specific protein tagging.

Application

• Site-Specific Protein Biotinylation: For introducing a cleavable biotin tag onto cysteine residues in proteins and antibodies for purification, pull-down assays, or immobilization.
• Proteomics Research: As a critical reagent in activity-based protein profiling (ABPP) and the study of protein-protein interactions.
• Diagnostic Kit Development: Used in the manufacturing of enzyme-linked immunosorbent assays (ELISAs) and other immunoassays that require stable, reversible biotin conjugation.
• Drug Discovery Platforms: For creating biotinylated drug candidates or targets in high-throughput screening and target identification workflows.
• Affinity Chromatography Ligand Synthesis: To functionalize resins and surfaces with cleavable biotin handles for the reversible capture of biomolecules.
• Structural Biology: Aiding in the preparation of samples for techniques like cryo-electron microscopy by providing a specific labeling strategy.

Basic Information

Product Name	n-Biotinylcaproylaminocaproylaminocaproylaminoethyl Methanethiosulfonate
CAS No.	1322625-00-2
Molecular Formula	C34H61N7O7S3
Molecular Weight	776.09 g/mol
Synonyms	Biotin-LC-LC-LC-MTS; Biotin-(LC)3-MTS; Biotinylated Methanethiosulfonate with Tri-Caproyl Spacer; N-Biotinyl-6-(6-(6-(2-(Methanethiosulfonato)ethylamino)hexanoylamino)hexanoylamino)hexanamide; Biotin-C6-C6-C6-MTS; Cleavable Biotin MTS Reagent; Biotin-Hexanoyl-Hexanoyl-Hexanoyl-Aminoethyl Methanethiosulfonate; Sulfhydryl-Reactive Cleavable Biotinylation Reagent
EINECS	Contact for details

Quality Control

Our n-Biotinylcaproylaminocaproylaminocaproylaminoethyl Methanethiosulfonate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance. Each lot undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and functional activity validation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Functional Activity	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.