Description

(S)-n-[(2S,4S,5S)-5-(Dibenzylamino)-4-Hydroxy-1,6-Diphenylhexan-2-Yl]-3-Methyl-2-(2-Oxotetrahydropyrimidin-1(2H)-Yl)Butanamide-D8 is a high-purity, deuterium-labeled derivative of a complex chiral amide, serving as a critical stable isotope-labeled internal standard for advanced analytical applications. Its primary value lies in enabling precise quantification and metabolic pathway tracing in complex biological matrices, ensuring data accuracy and regulatory compliance. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require reliable reference materials for method development and validation.

Application

• Liquid Chromatography-Mass Spectrometry (LC-MS/MS) Internal Standard: Used for the accurate quantification of the non-deuterated parent compound in bioanalytical studies, pharmacokinetics (PK), and drug metabolism and pharmacokinetics (DMPK) research.
• Metabolic Pathway and Stability Studies: Facilitates the investigation of drug metabolism, identification of metabolites, and assessment of in vitro and in vivo stability.
• Pharmaceutical Impurity Profiling and Method Validation: Acts as a critical reference standard in analytical method development and validation to ensure specificity, accuracy, and precision for regulatory filings.
• Preclinical and Clinical Research: Supports drug discovery and development processes by providing a reliable isotopic tracer for absorption, distribution, metabolism, and excretion (ADME) studies.
• Quality Control and Assurance: Serves as a certified reference material (CRM) in pharmaceutical quality control laboratories to calibrate equipment and verify analytical procedures.

Basic Information

Product Name	(S)-n-[(2S,4S,5S)-5-(Dibenzylamino)-4-Hydroxy-1,6-Diphenylhexan-2-Yl]-3-Methyl-2-(2-Oxotetrahydropyrimidin-1(2H)-Yl)Butanamide-D8
CAS No.	1322623-80-2
Molecular Formula	C41H44D8N4O3
Molecular Weight	~656.92 g/mol
Synonyms	Deuterated (S)-n-[(2S,4S,5S)-5-(Dibenzylamino)-4-Hydroxy-1,6-Diphenylhexan-2-Yl]-3-Methyl-2-(2-Oxotetrahydropyrimidin-1(2H)-Yl)Butanamide; Butanamide-D8, (S)-N-[(2S,4S,5S)-5-(Dibenzylamino)-4-hydroxy-1,6-diphenyl-2-hexanyl]-3-methyl-2-(2-oxo-1(2H)-pyrimidinyl)-; Deuterated Chiral Amide Internal Standard; Stable Isotope-Labeled Amide; CAS 1322623-80-2; (S)-n-[(2S,4S,5S)-5-(Dibenzylamino)-4-Hydroxy-1,6-Diphenylhexan-2-Yl]-3-Methyl-2-(2-Oxotetrahydropyrimidin-1(2H)-Yl)Butanamide (d8); 1322623-80-2
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure isotopic purity, chemical purity, and batch-to-batch consistency. Each lot undergoes comprehensive analysis, including NMR (¹H, ¹³C) for structural and isotopic confirmation, HPLC for chemical purity, and LC-MS for identity and isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support compliance with ICH Q2(R1), USP, and other relevant pharmaceutical guidelines for analytical procedures.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants or inert atmosphere sealing.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.